University of Lucerne (Universität luzern; English: University of Lucerne) Switzerland's youngest public university, founded in 2000, is located in the center of Lucerne, the German-speaking part of Switzerland, the focus of humanities and social sciences, the main faculties are the Faculty, the Faculty of Humanities and Social Sciences, the Faculty of Law The main faculties are the Faculty of Humanities, the Faculty of Humanities and Social Sciences, and the Faculty of Law.

EF Education First (EF) is a leading global education and training organization founded in 1965 and headquartered in Lucerne, Switzerland. EF Education First offers language learning, educational travel, cultural exchange and many other educational programs in more than 50 countries and regions around the world.

The Fachhochschule Ostschweiz (FHO; Fachhochschule Ostschweiz) is a Swiss national professional university founded in 1995, located in the German-speaking part of Switzerland, a member of the International Federation of Universities of Lake Constance, and one of the participating universities of the European Erasmus exchange program. The faculties are located in St. Gallen, Labossiere, Kull and Bux.

The Federal Institute for Materials Testing and Development (EMPA; Eidgenössische Materialprüfungs-und Forschungsanstalt), a leading Swiss institution of higher learning in materials research, was founded in 1880 in Switzerland. It was founded in 1880 in the German-speaking part of Switzerland and is dedicated to the study of application-oriented materials.

PHSG (Pädagogische Hochschule St. Gallen) Switzerland's top teacher training college, formed by the merger of two former teacher training colleges in St. Gallen and Rorschach on September 1, 2007, is located in St. Gallen, the German-speaking part of Switzerland.

The University of Ticino (USI; Università della Svizzera italiana; Swiss Italian University) is Switzerland's leading public interdisciplinary and multilingual university, the only public university in the Italian-speaking part of Switzerland, founded in 1996 and located in Lugano, the largest city in the canton of Ticino in southern Switzerland. Lugano, the largest city in the southern Swiss canton of Ticino, has four faculties: Economics, Communication Sciences, Informatics and Architecture, of which the Faculty of Architecture is the world-renowned Mendrisio School of Architecture. The School of Architecture is the world-renowned Mendrisio School of Architecture;

University of Lausanne (French: Université de Lausanne, UNIL) is a historic university in Switzerland, its history can be traced back to the creation of Schola Lausannensis in 1573, officially upgraded to a university in 1890. The University of Lausanne has the School of Theology and Religious Studies, the School of Law and Justice, the School of Arts, and the Lausanne Higher School of Business.