United Press International (UPI) is the second largest news agency in the United States. UPI is the second largest news agency in the United States, one of the four largest news agencies in the world, a for-profit commercial news agency formed in May 1958 by the merger of UPI and News International, with headquarters in Washington, D.C., and its news and photo distribution network centered in New York. It is headquartered in Washington, D.C., and its news and photo distribution network is based in New York;