The Johns Hopkins Hospital is a major U.S. general hospital built in 1889 in Baltimore, Maryland. Johns Hopkins Hospital has been ranked as one of the best hospitals in the nation for more than 20 years (ranked third in 2014-2015). Johns Hopkins has had a profound impact on the development of medicine, having performed the world's first complete sex change surgery, the first neonatal surgery for tetralogy of Fallot, the first heart bypass, the first isolation of the polio virus, and the first use of rubber gloves in surgery. Renal dialysis and cardiopulmonary resuscitation were first started at Johns Hopkins.