Panerai moved its watchmaking workshop to Piazza San Giovanni in Florence, which is still the main store of the watchmaker. The words "Orologeria Svizzera" (Swiss watch store) on the signboard at the entrance are still vaguely recognizable, clearly emphasizing that Panerai is of noble Swiss origin.

In addition, the Manufacture also began to supply optical and mechanical tools to the Italian Ministry of Defence.

In 1910

the Manufacture began to develop luminous substances for instrument dials, scopes and telescopic devices, and finally succeeded in combining zinc sulfide and radioactive bromine to develop the luminous Radiomir. The mixture, when placed in a small glass tube, can effectively extend its life. With this successful invention, Guido Panerai was able to obtain patents in Italy and other countries.

1915-1918

The Italian Royal Navy used precision instruments made by Panerai during the First World War, including luminous devices for night-attack gun sights, chronographs, and depth measuring instruments. These included the luminescent device for the night attack gun sight, the timekeeping device, the depth measuring device, and the mechanical calculator to assist the high-speed torpedo steamer (MAS) in launching torpedoes.

2011